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Filtered Search Results
Apexbio Technology LLC BGJ398(Synonyms: Infigratinib, NVP-BGJ398, BGJ-398, BGJ 398), 200mg, CAS: 872511-34-7.
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BGJ398 (CAS 872511-34-7) also known as NVP-BGJ398 is an orally bioavailable small-molecule inhibitor targeting fibroblast growth factor receptors (FGFRs) It selectively inhibits receptor tyrosine kinase activity of FGFR1 FGFR2 FGFR3 and FGFR4 which are critical mediators in signal transduction pathways involved in cell proliferation differentiation and survival In preclinical studies BGJ398 suppresses proliferation and induces apoptosis in FGFR-dependent cancer cells additionally it demonstrates antitumor activity in xenograft tumor models BGJ398 is utilized as a research tool in oncology studies investigating FGFR-driven malignancies
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eMolecules 101-38-2 | Gibbs reagent | TargetMol | MFCD00001611 | 210.440 | C6H2Cl3NO | 0.000 | ClN=C1C=C(Cl)C(=O)C(Cl)=C1 | 200mg | 761052535
Gibbs reagent | TargetMol | 101-38-2 | MFCD00001611 | 210.440 | C6H2Cl3NO | 0.000 | ClN=C1C=C(Cl)C(=O)C(Cl)=C1 | 200mg | 761052535
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000770639 3 6-DINITRO-9H-CARBA 500MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000266535 EDOXABAN IMPURITY 59 25MG
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Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.90% | 1 ML
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Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist that readily crosses the blood-brain barrier. It stimulates [35S]-GTPγS binding at the D2 dopamine receptor expressed in CHO cells with a pEC50 of 8.15±0.05. It also acts as a strong inhibitor of brain nitric oxide synthase and a potent inhibitor of CYP3A4.
- It is a potent dopamine D2/D3 receptor agonist.
- It is permeable to the blood-brain barrier.
- It shows significant anti-immobility action in experimental models of depression.
- It induces a significant, dose-dependent decrease in pain scores in specific models.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000770654 ACRIDINE-9-CARBOXALD 1G
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Apexbio Technology LLC Bitopertin(Synonyms: RG1678, RO4917838, RG-1678, RO-4917838), 200mg, CAS: 845614-11-1.
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Bitopertin (CAS 845614-11-1) also known as RG1678 is a selective inhibitor of glycine transporter-1 (GlyT1) exhibiting an EC50 of 30 nM in vitro GlyT1 inhibition increases synaptic glycine a co-agonist at N-methyl-D-aspartate (NMDA) receptor glycine-binding sites thereby enhancing NMDA receptor-mediated glutamatergic neurotransmission This mechanism addresses glutamatergic dysfunction implicated in schizophrenia Clinical studies indicate that adjunctive bitopertin treatment improves negative symptoms in schizophrenia patients highlighting its therapeutic potential as a GlyT1-targeted research tool and drug candidate
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Medchemexpress LLC Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9S)- | 1435-55-8 | 99.97% | 10 G
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Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker that exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. It also prolongs the QT interval and demonstrates antiarrhythmic efficacy.
- Strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
- Prolongs the QT interval
- Demonstrates antiarrhythmic efficacy
- Has anti-clonogenic and anti-tumorigenic activities on pancreatic cancer cells in vitro
- For research use only
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Medchemexpress LLC Hydroquinidine | 1435-55-8 | 99.9% | 1 ML
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Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker that demonstrates strong anti-cancer activity against colon, pancreatic, and hepatocellular cancer cells. It also prolongs the QT interval and possesses antiarrhythmic efficacy.
- Potent ion channel blocker
- Exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
- Prolongs the QT interval
- Possesses antiarrhythmic efficacy
- For research use only
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eMolecules 1805137-37-4 | 3-Bromo-2-chloro-4-(difluoromethoxy)pyridine | MFCD28733844 | 250mg
Ambeed | (4S4S)-22-(23-Dihydro-1H-indene-22-diyl)bis(4-(tert-butyl)-45-dihydrooxazole) | 100mg | 633659832 | A1220210 | 2757082-06-5 | 368.521 | C23H32N2O2
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Medchemexpress LLC Olmutinib | 1353550-13-6 | 99.5% / 99.9% | 486.59 | 200 MG
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Olmutinib is an orally active and irreversible third-generation EGFR tyrosine kinase inhibitor. It binds to a cysteine residue near the kinase domain and is used for Non-Small Cell Lung Cancer (NSCLC). This product is for research use only.
- Orally active
- Irreversible third-generation EGFR tyrosine kinase inhibitor
- Binds to a cysteine residue near the kinase domain
- Used for Non-Small Cell Lung Cancer (NSCLC)
- For research use only
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Apexbio Technology LLC Carboxine 5234-68-4 200mg
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Carboxine (5234-68-4) is a small-molecule inhibitor targeting mitochondrial succinate dehydrogenase (SDH) It is designed to inhibit SDH activity thereby interfering with fungal cellular respiration pathways Carboxine exerts its biological activity primarily through inhibition of mitochondrial SDH In in vitro studies Carboxine demonstrates inhibitory efficacy with IC50 values typically in a micromolar range depending on fungal species and assay conditions Based on these pharmacological properties Carboxine holds research potential in studying mitochondrial metabolism energy production pathways fungicidal resistance mechanisms and assessment of biochemical impacts of SDH inhibition within fungal cells
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Medchemexpress LLC RU.521 100mg | 2262452-06-0 | 100 MG
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RU.521 is a small-molecule inhibitor of cyclic GMP-AMP synthase (cGAS) used in research to suppress cGAS-mediated interferon signaling. It is supplied as a high-purity solid and is provided in multiple sizes and formulations for in vitro and cellular studies.
- High purity (99.95%) for reproducible results.
- Potent, selective inhibition of cGAS in cellular assays.
- Available in multiple sizes and DMSO solution formats for flexibility.
- Stable as a powder at -20°C for long-term storage.
- Molecular weight 415.23; formula C19H12Cl2N4O3.
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Apexbio Technology LLC Quinine HCl Dihydrate 6119-47-7 10mM (in 1mL DMSO)
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Quinine HCl Dihydrate is a quinoline alkaloid hydrochloride salt presented as a dihydrate form It exerts its biological activity primarily through interference with heme detoxification mechanisms within Plasmodium species disrupting parasite-mediated heme metabolism and inducing cytotoxic free heme accumulation At the molecular level quinoline derivatives may inhibit nucleic acid synthesis affecting DNA replication and transcription events during erythrocytic lifecycle stages Researchers frequently utilize Quinine HCl Dihydrate for studies on antimalarial drug mechanisms parasite resistance pathways and as a reference standard in pharmacological and pharmacokinetic assessments
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Apexbio Technology LLC AM966 1228690-19-4 200mg
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AM966 (CAS 1228690-19-4) is an orally bioavailable small-molecule antagonist that selectively targets Lysophosphatidic acid type 1 receptor (LPA1) AM966 exhibits potent inhibitory activity against LPA1 receptors from humans and mice with IC50 values of approximately 17 nM and 19 nM respectively demonstrating selectivity over other LPA receptor subtypes (LPA2 5) In vitro AM966 blocks LPA-mediated chemotactic responses in IMR-90 human lung fibroblasts A2058 human melanoma cells and CHO cell lines In vivo AM966 effectively attenuates lung fibrosis inflammation and associated weight loss in bleomycin-induced murine pulmonary fibrosis models highlighting its utility in research on fibrotic diseases
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