Quinolines and derivatives
Apexbio Technology LLC Isocytosine 108-53-2 200mg
Isocytosine (CAS 108-53-2) is a non-canonical nucleobase and a structural isomer of cytosine It serves as an analog in nucleic acid research notably as a component of expanded genetic systems such as hachimoji RNA and can pair with isoguanine to model non-standard base pairing Mechanistically isocytosine has been shown to modulate specific signaling pathways and enzyme activities in experimental systems It is widely utilized in molecular biology and genetics to investigate alternative base-pairing nucleic acid stability and the physicochemical properties of synthetic genetic polymers
Medchemexpress LLC Madecassoside | 34540-22-2 | 975.12 | 200 MG
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica with anti-inflammatory, antioxidant, and anti-aging properties. It is orally active and inhibits inflammation, oxidation, apoptosis, and autophagy by inhibiting p38 MAPK and NF-κB activities, exhibiting anti-apoptotic properties, and activating Nrf2 expression. It has potential applications in endocrine, cardiovascular, and skin diseases.
- Isolated from Centella asiatica.
- Anti-inflammatory, antioxidant, and anti-aging effects.
- Orally active.
- Inhibits inflammation, oxidation, apoptosis, and autophagy.
- Inhibits p38 MAPK and NF-κB activities.
- Exhibits anti-apoptotic properties.
- Activates Nrf2 expression to reduce neurotoxicity.
- Potential for endocrine, cardiovascular, and skin diseases.
Medchemexpress LLC Prucalopride succinate | 179474-85-2 | 99.9% | 200 MG
Prucalopride succinate is an orally active, selective, and specific 5-HT4 receptor agonist. It enhances intestinal motility by promoting intestinal nervous system regeneration and exhibits anticancer activity by blocking the PI3K/AKT/mTor pathway. It is used in studies of chronic constipation, pseudo-intestinal obstruction, and cancer.
- Selective and specific 5-HT4 receptor agonist
- Enhances intestinal motility
- Exhibits anticancer activity
- Induces autophagy and apoptosis in A549/A427 cells
- Promotes regeneration of colonic neural stem cells and neurons
Medchemexpress LLC Piperacillin sodium | 59703-84-3 | 98.22% | 200 MG
Piperacillin sodium is a semisynthetic broad-spectrum β-lactam antibiotic that exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. It is most commonly used in combination with the β-lactamase inhibitor Tazobactam.
- Exhibits potent bactericidal activity
- Effective against Gram-negative bacteria
- Effective against select Gram-positive strains
- Targets penicillin-binding proteins
- Commonly used with β-lactamase inhibitor
eMolecules Pharmablock / 2-methylpyridine-4-carbaldehyde / 25mg / 551173886 / PBYS1352 / 0.000 / 63875-01-4 / MFCD06410683 / 121.139 / C7H7NO
Pharmablock / 2-methylpyridine-4-carbaldehyde / 25mg / 551173886 / PBYS1352 / 0.000 / 63875-01-4 / MFCD06410683 / 121.139 / C7H7NO
Medchemexpress LLC Darunavir Ethanolate | 635728-49-3 | 99.9% | 593.73 | 200 MG
Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. It has a Ki of 1 nM for wild type HIV-1 protease.
- Broad-spectrum potent inhibitor active against HIV-1 clinical isolates with minimal cytotoxicity.
- Forms hydrogen bonds with the conserved main-chain atoms of Asp29 and Asp30 of the protease, critical for potency against HIV isolates resistant to multiple protease inhibitors.
- Shows greater potency than other inhibitors in MT-2 cells.
- Primarily metabolized by hepatic cytochrome P450 (CYP) enzymes, mainly CYP3A.
- Is effective against wild-type and PI-resistant HIV.
- Has an oral bioavailability of 37%, which increases to 82% when combined with ritonavir.
Medchemexpress LLC Oxyclozanide | 2277-92-1 | 98.7% | 401.46 | 200 MG
Oxyclozanide is an orally active salicylanilide anthelmintic agent that primarily functions by uncoupling oxidative phosphorylation in flukes. It also exhibits good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activities.
- Orally active salicylanilide anthelmintic agent.
- Mainly acts by uncoupling oxidative phosphorylation in flukes.
- Shows good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity.
- Effective against meticillin-sensitive and meticillin-resistant S. pseudintermedius isolates.
- Inhibits methicillin-resistant S. aureus (MRSA).
- Demonstrates antiparasitic effectiveness in sheep and cattle.
![Medchemexpress LLC Benzeneacetonitrile, 4-[(4-methoxyphenyl)methoxy]- | 175135-47-4 | 98.1% | 253.30 | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000388214-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzeneacetonitrile, 4-[(4-methoxyphenyl)methoxy]- | 175135-47-4 | 98.1% | 253.30 | 200 MG
O4I1 is a potent Oct3/4 inducer that enhances Oct3/4 gene expression, increases Oct3/4 protein levels, and promotes Oct3/4 mediated transcriptional activation. It activates Oct3/4 at both transcriptional and translational levels in various human cell lines and is sufficient to enhance Oct3/4 overexpression by 2-fold and 3-fold after 48 and 72 hours of treatment, respectively.
- Potent Oct3/4 inducer.
- Enhances Oct3/4 gene expression.
- Increases Oct3/4 protein levels.
- Promotes Oct3/4 mediated transcriptional activation.
- Activates Oct3/4 at transcriptional and translational levels in diverse human cell lines.
- Can enhance Oct3/4 overexpression 2-fold and 3-fold after 48 and 72 hours of treatment in untransfected HEK293 cells.
Medchemexpress LLC Purvalanol B (NG 95) | 212844-54-7 | 97.0% | 432.90 | 200 MG
Purvalanol B (NG 95) is a potent, selective, reversible, and ATP-competitive inhibitor of cyclin-dependent kinases (CDK). It demonstrates significant selectivity for CDK over other protein kinases and effectively inhibits the growth of a chloroquine-resistant strain of *P. falciparum*.
- Potent, selective, reversible, and ATP-competitive inhibitor of CDK
- Inhibits cdc2-cyclin B, CDK2-cyclin A, and CDK5-p35 with IC50s of 6 nM
- Inhibits CDK2-cyclin E with an IC50 of 9 nM
- Shows selectivity for CDK over other protein kinases (IC50 > 1000 nM)
- Inhibits the growth of a chloroquine-resistant strain of *P. falciparum*
Medchemexpress LLC TMP269 | 1314890-29-3 | 98.2% | 514.52 | 200 MG
TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor, targeting HDAC4, HDAC5, HDAC7, and HDAC9. It is intended for research use only. TMP269 modulates cell cycle progression and enhances cytotoxicity in certain cell lines, without affecting class I or IIb HDACs. It has also shown antiangiogenic effects in vivo.
- Novel and selective class IIa histone deacetylase (HDAC) inhibitor
- Targets HDAC4, HDAC5, HDAC7, and HDAC9
- Modulates cell cycle progression in IEC-18 intestinal epithelial cells
- Enhances CFZ-induced cytotoxicity in MM cell lines
- No inhibitory effects on class I or IIb HDACs
- Demonstrates antiangiogenic effects in vivo
TARGETMOL CHEMICALS INC Telmisartan 200MG
Also available in 1 g, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Telmisartan (BIBR 277) is an Angiotensin 2 Receptor Blocker. The mechanism of action of telmisartan is as an Angiotensin 2 Receptor Antagonist. Purity 98.78%
Apexbio Technology LLC Eltrombopag 496775-61-2 200mg
Eltrombopag is a small molecule orally bioavailable non-peptide agonist targeting the thrombopoietin (TPO) receptor also known as c-Mpl receptor Upon activating this receptor pathway eltrombopag promotes intracellular signaling leading to increased proliferation and differentiation of megakaryocyte progenitor cells thereby stimulating platelet production (thrombopoiesis) In biochemical assays eltrombopag shows potent activity exhibiting an IC50 value of approximately 0 69 M As a research tool this compound is utilized widely in studies investigating mechanisms regulating platelet homeostasis thrombocytopenia-related diseases and efforts to elucidate novel therapeutic strategies targeting hematopoietic lineage differentiation
Apexbio Technology LLC GSK1838705A 1116235-97-2 200mg
GSK1838705A (CAS 1116235-97-2) is a small molecule inhibitor targeting the kinase activity of insulin-like growth factor-1 receptor (IGF-1R) insulin receptor and anaplastic lymphoma kinase (ALK) It exhibits potent inhibition with IC50 values of 2 0 nM for IGF-1R 1 6 nM for insulin receptor and 0 5 nM for ALK In preclinical research GSK1838705A suppresses proliferation of hematologic malignancy-derived tumor cells including multiple myeloma and Ewing sarcoma lines and inhibits tumor xenograft growth in vivo Additionally despite targeting the insulin receptor it minimally affects glucose homeostasis at effective doses Due to its multi-target kinase inhibitory profile GSK1838705A serves as a promising tool for cancer biology research
Medchemexpress LLC Apilimod | 541550-19-0 | 99.8% | 418.49 | 200 MG
Apilimod is a potent IL-12/IL-23 inhibitor, strongly inhibiting IL-12 with IC50s of 1 nM and 2 nM in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively. It is also described as a potent and highly selective PIKfyve inhibitor.
- Potent IL-12/IL-23 inhibitor
- Strongly inhibits IL-12 with IC50s of 1 nM and 2 nM
- Potent and highly selective PIKfyve inhibitor
- Inhibits IFN-γ production in human PBMCs
- Reduces severity of experimental autoimmune uveoretinitis (EAU)
- Lowers level of IL-12 p40 in serum without altering body weight in EAU mice
- Effective in Th1 model, with 51%±8% inhibition
Medchemexpress LLC Veliparib | 912444-00-9 | MFCD16661059 | 244.29 g/mol | C13H16N4O | 200 MG
Veliparib (ABT-888) is a small-molecule inhibitor of poly(ADP-ribose) polymerases used in research to probe DNA repair pathways and for chemosensitization studies. It is supplied as a solid for analytical and preclinical research and has documented storage recommendations for powder and solutions.
- Potent PARP1 and PARP2 inhibition (Ki 5.2 nM and 2.9 nM).
- Molecular formula C13H16N4O and molecular weight 244.29 g/mol.
- Identified by CAS number 912444-00-9.
- Supplied as a powder with recommended storage: -20°C (3 years) or 4°C (2 years).
- Stable in solvent when stored at -80°C (1 year) or -20°C (6 months).